Due to the amount of minority compounds in Extra Virgin Olive Oil (EVOO), many scientific studies have been published which confirm the health benefits that EVOO can bring.
There is extensive information about the healthy properties of Extra Virgin Olive Oil and it is important to always link these claims to scientific references. A recent ban on offering direct claims on EVOO labelling, despite the extensive scientific evidence, has driven QvExtra! International to try to disclose and defend the Extra Virgin Olive Oil culture. The association has carried out a comprehensive literature review, where more than 40 international scientific studies identifying its health benefits for human consumption have been analysed. Among the benefits of EVOO identified in these scientific studies analysed, the following have been highlighted:
- Very healthy properties with its consumption (6, 19, 20, 39, 12)
- Improving the body’s general health due to its content of phenolic compounds (25)
- Reduction of pain caused by the increase of enkephalin (9)
- EVOO’s protective effect on memory alterations or synaptic integration (29, 30)
- Positive effects on the intestine microbiota (14)
- Obesity control due to its inverse relationship with its content of monounsaturated fatty acids (3, 18, 31)
- Anti-inflammatory properties (2, 4, 24)
- Blood pressure control (5, 41)
- Regulation of cardiovascular diseases (7, 10, 11, 16, 21, 33, 35, 36)
- Prevention of type 2 diabetes (8, 17, 22, 31)
- A certain extent of relief in severe fatty livers (13, 28)
- Improvement of pancreatitis (34)
- Improvement of liver function (1, 23, 38)
- Maintenance of brain homeostasis (15)
- Beneficial effects on breast cancer or type 2 diabetes mellitus (22, 31, 33)
- Prevention of neurological disorders, inflammatory complications and cancer (24)
- Control prostate cancer due to the oncogene regulations from oleic acid (37)
- Antimicrobial and antiviral properties (27, 32, 40, 42)
References:
1- Maternal diets enriched in olive oil regulate lipid metabolism and levels of PPARs and their coactivators in the foetal liver in a rato model of gestational diabetes mellitus.
Improved foetal liver metabolism in maternal diets enriched in olive oil
Evidence of significant effects of a maternal diet enriched un olive oil on foetal liver metabolism, which may improve the metabolic health of the new generation.
https://www.sciencedirect.com/science/article/abs/pii/S0955286319304887?via%3Dihub
Reference: Fornes, D., Gomez Ribot, D., Heinecke, F., Roberti, S., Capobianco, E., & Jawerbaum, A. (2020). The Journal Of Nutritional Biochemistry, 78, 108334. doi: 10.1016/j.jnutbio.2019.108334
2- Is olive oil good for you? A systematic review and meta-analysis on anti-inflamatory benefits from regular dietary intake.
EVOO with anti-inflammatory potential
Benefits of olive oil in its anti-inflammatory role.
https://www.sciencedirect.com/science/article/pii/S0899900719301182?via%3Dihub
Reference: Fernandes, J., Fialho, M., Santos, R., Peixoto-Plácido, C., Madeira, T., & Sousa-Santos, N. et al. (2020). Nutrition, 69, 110559. doi: 10.1016/j.nut.2019.110559
3- Exclusive olive oil consumption was favourably associated with metabolic indices and lifestyle factors in schoolchildren.
EVOO as the main source of monounsaturated fatty acids inversely related to the probability of suffering from obesity
This study supports the exclusive use of olive oil in school canteens, finding an inversely proportional relationship with obesity.
https://www.sciencedirect.com/science/article/pii/S074000201830306X?via%3Dihub
Reference: Tambalis, K., Panagiotakos, D., Psarra, G., & Sidossis, L. (2020). Nutrition, Metabolism And Cardiovascular Diseases, 30(4), 566-573. doi: 10.1016/j.numecd.2019.12.004
4- The mediterranean diet decreases prothrombotic microvesicle release in asymptomatic individuals at high cardiovascular risk.
Reduced inflammation in a Mediterranean diet rich in EVOO
The study associates a delay in the development of cardiovascular complications with the consumption of a Mediterranean diet rich in EVOO.
https://www.sciencedirect.com/science/article/abs/pii/S0261561420300911
Reference: Chiva-Blanch, G., Sala-Vila, A., Crespo, J., Ros, E., Estruch, R., & Badimon, L. (2020). Clinical Nutrition. doi: 10.1016/j.clnu.2020.02.027
5- Capacidad aeróbica, dieta mediterránea y factores de riesgo cardio metabólicos en adultos.
Analysis of the relationship between the consumption of a Mediterranean diet and blood pressure modulation.
The study associates low adherence to the Mediterranean diet with an increased overall cardio-metabolic risk.
https://www.sciencedirect.com/science/article/abs/pii/S253001641930120X
Reference: Rebollo-Ramos, M., Velázquez-Díaz, D., Corral-Pérez, J., Barany-Ruiz, A., Pérez-Bey, A., & Fernández-Ponce, C. et al. (2020). Endocrinología, Diabetes Y Nutrición, 67(2), 113-121. doi: 10.1016/j.endinu.2019.04.004
6- Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018
Active compounds in EVOO that make its properties very healthy for consumption.
This article relates the health benefits of EVOO consumption with its active compounds.
https://www.mdpi.com/2072-6643/11/9/2039
Reference: Gaforio, Visioli, Alarcón-de-la-Lastra, Castañer, Delgado-Rodríguez, Fitó, Hernández, Huertas, Martínez-González, Menendez, Osada, Papadaki, Parrón, Pereira, Rosillo, Sánchez-Quesada, Schwingshackl, Toledo and Tsatsakis, 2019. Nutrients, 11(9), p.2039.
7- Genetic Resources in Relation to the Content of Vitamin E in Virgin Olive Oil.
New varieties of EVOO with a high vitamin E content
The study identifies olive varieties with a high vitamin E content and their beneficial relationship with the cardiovascular system.
https://www.ncbi.nlm.nih.gov/pubmed/31349630
Reference: Pérez, A., León, L., Pascual, M., de la Rosa, R., Belaj, A. and Sanz, C., 2019. Analysis of Olive (Olea Europaea L.) Antioxidants, 8(8), p.242
8- Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The PREDIABOLE study, a randomized controlled trial.
Development of a new type of preventive olive oil against type 2 diabetes
Development of a new type of olive oil that has served to demonstrate its use as a preventive functional food against type 2 diabetes.
https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.13838
Reference: Santos‐Lozano, J., Rada, M., Lapetra, J., Guinda, Á., Jiménez‐Rodríguez, M., Cayuela, J., Ángel‐Lugo, A., Vilches‐Arenas, Á., Gómez‐Martín, A., Ortega‐Calvo, M. and Castellano, J., 2019. Diabetes, Obesity and Metabolism, 21(11), pp.2526-2534.
9- Extra virgin olive oil improves synaptic activity, short‐term plasticity, memory, and neuropathology in a tauopathy model.
Link between EVOO consumption and increase in pain-reducing enkephalins
The study links EVOO consumption with the production of certain pain-reducing neuronal substances called enkephalins.
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13076
Reference: Lauretti, E., Nenov, M., Dincer, O., Iuliano, L. and Praticò, D., 2019. Aging Cell, 19(1).
10- Extra- virgin olive oil for potential prevention of Alzheimer disease.
Decrease in the probability of suffering cardiovascular factors leading to changes in Alzheimer’s disease with the consumption of monounsaturated fats from EVOO.
This article considers the study of dietary therapy to be of relevant importance when observing the modifications that Alzheimer’s disease causes, due to the very important role that cardiovascular factors play in the development of the disease.
https://www.sciencedirect.com/science/article/pii/S0035378719307283
Reference: Román, G., Jackson, R., Reis, J., Román, A., Toledo, J., & Toledo, E. (2019). Revue Neurologique, 175(10), 705-723. doi: 10.1016/j.neurol.2019.07.017
11- Adherencia a la dieta mediterránea en pacientes diabéticos con mal control.
Study on the relationship between the Mediterranean diet, EVOO consumption and better control of cardiovascular risk factors
This study shows that adherence to a Mediterranean diet rich in EVOO is related to better control of cardiovascular risk factors.
https://www.elsevier.es/es-revista-clinica-e-investigacion-arteriosclerosis-15-articulo-adherencia-d ieta-mediterranea-pacientes-diabeticos-S0214916819300488
Reference: Celada Roldan, C., Tarraga Marcos, M., Madrona Marcos, F., Solera Albero, J., Salmeron Rios, R., & Celada Rodriguez, A. et al. (2019). Clínica E Investigación En Arteriosclerosis, 31(5), 210-217. doi: 10.1016/j.arteri.2019.03.005
12- Evaluation of physiological properties of yeast strains isolated from olive oil and their in vitro probiotic trait.
Probiotic properties in humans from yeasts cultured in EVOO
This study observes how yeasts incubated in olive oil as a medium show interesting characteristics with respect to their probiotic potential for humans.
https://www.sciencedirect.com/science/article/pii/S074000201830306X?via%3Dihub
Reference: Zullo, B., & Ciafardini, G. (2019). Food Microbiology, 78, 179-187. doi:10.1016/j.fm.2018.10.016.
13- Olive oil lessened fatty liver severity independent or cardiometabolic correction in patients with non-alcoholic liver disease: A randomized critical trial.
A certain degree of relief for some liver disease severity with EVOO consumption
This study concludes that olive oil can alleviate the severity of fatty liver disease independent of cardio metabolic factors.
https://www.sciencedirect.com/science/article/abs/pii/S0899900718301023?via%3Dihub
Reference: Rezaei, S., Akhlaghi, M., Sasani, M., & Barati Boldaji, R. (2019). Nutrition, 57, 154-161. doi: 10.1016/j.nut.2018.02.021
14- Health benefits of olive oil and its components: Impacts on gut microbiota antioxidant activities, and prevention of non-communicable diseases.
Positive effects on intestinal microbiota with EVOO consumption
The consumption of extra virgin olive oil can have positive effects on the prevention of cancer and type 2 diabetes. Its use is not only recommended because of the healthy fatty acids it contains but also because of the positive effect of bioactive compounds on human health, such as those that contribute to the intestinal microbiota.
https://www.sciencedirect.com/science/article/abs/pii/S0924224419300779
Reference: Gavahian, M., Mousavi Khaneghah, A., Lorenzo, J., Munekata, P., Garcia-Mantrana, I.,
- Collado, et al. (2019). Trends In Food Science & Technology, 88, 220-227. doi:10.1016/j.tifs.2019.03.00
15- Unsaponifiable and phenolic fractions from virgin olive oil prevent neuroinflammation skewing microglia polarization toward M2 phenotype.
Maintenance of brain homeostasis with a diet whose predominant fat is EVOO
The study found low neuroinflammation and maintenance of brain homeostasis when the predominant fat in the diet is olive oil, with its minor components being the cause.
https://digital.csic.es/handle/10261/190450
Reference: Toscano, R., Millan-Linares, M., Naranjo, M., Lemus-Conejo, A., Claro, C., & Montserrat-de la Paz, S. (2019). Journal Of Functional Foods, 62, 103543. doi: 10.1016/j.jff.2019.103543
16- Mediterranean diet, cardiovascular disease and mortality in diabetes: A systematic review and meta-analysis of prospective cohort studies and randomized clinical trials.
Decreased risk of cardiovascular disease in populations, including people with diabetes, with the incorporation of the Mediterranean diet into the diet.
Meta-analysis of the effects of the Mediterranean diet on the prevention of cardiovascular disease and its impact on mortality, concluding that this diet has beneficial effects in populations including individuals with diabetes.
https://www.tandfonline.com/doi/full/10.1080/10408398.2019.1565281
Reference: Becerra-Tomás, N., Blanco Mejía, S., Viguiliouk, E., Khan, T., Kendall, C., Kahleova, H., Rahelić, D., Sievenpiper, J. and Salas-Salvadó, J., 2019. Critical Reviews in Food Science and Nutrition, 60(7), pp.1207-1227.
17- Reduction in the Incidence of Type 2 Diabetes with the Mediterranean Diet: Results of the PREDIMED-Reus nutrition intervention randomized trial.
Reductions in the incidence of type 2 diabetes due to the Mediterranean diet
Confirmation of the results obtained in previous PREDIMED studies showing a reduction in the incidence of type 2 diabetes due to the consumption of the Mediterranean diet.
https://care.diabetesjournals.org/content/41/10/2259
Reference: Salas-Salvado, J., Bullo, M., Babio, N., Martinez-Gonzalez, M., Ibarrola-Jurado, N., Basora, J., Estruch, R., Covas, M., Corella, D., Aros, F., Ruiz-Gutierrez, V. and Ros, E., 2010. Diabetes Care, 34(1), pp.14-19.
18- Adherence to Mediterranean Diet or Physical Activity After Bariatric Surgery and Its Effects on Weight Loss, Quality of Life, and Food Tolerance.
Olive oil as the best option to include in a low-calorie diet.
Relationship between weight loss when following the Mediterranean diet and olive oil consumption.
https://link.springer.com/article/10.1007%2Fs11695-019-04242-3
Reference: Gils Contreras, A., Bonada Sanjaume, A., Becerra-Tomás, N. and Salas-Salvadó, J., 2019. Obesity Surgery, 30(2), pp.687-696.
19- Using Extra Virgin Olive Oil to Cook Vegetables Enhances Polyphenol and Carotenoid Extractability: A Study Applying the sofrito Technique.
Cooking vegetables with EVOO enhances the absorption and release of bioactive compounds from their original ingredients.
The study concludes that the use of EVOO in Mediterranean cuisine can support the extractability of bioactive compounds such as polyphenols and carotenoids from the food itself.
https://www.mdpi.com/1420-3049/24/8/1555
Reference: Rinaldi de Alvarenga, J., Quifer-Rada, P., Francetto Juliano, F., Hurtado-Barroso, S., Illan, M., Torrado-Prat, X. and Lamuela-Raventós, R., 2019. Molecules, 24(8), p.1555.
20- Terapias antienvejecimiento aplicadas a la enfermedad de Alzheimer.
Consumption of EVOO in our diet increases life expectancy
The study shows a high degree of relationship between the traditional Mediterranean diet and increased life expectancy, lower incidence of cardiovascular disease and lower mortality, lower risk of cancer, less age-related cognitive decline and lower risk of chronic diseases.
https://www.elsevier.es/es-revista-revista-espanola-geriatria-gerontologia-124-articulo-terapias-a ntienvejecimiento-aplicadas-enfermedad-alzheimer-S0211139X17300616
Reference: Alonso Abreu, G., Brito Armas, J., & Castro Fuentes, R. (2018). Revista Española De Geriatría Y Gerontología, 53(1), 45-53. doi: 10.1016/j.regg.2017.02.007
21- La dieta mediterránea, óptima contra las enfermedades cardiovasculares, pero poco seguida por supervivientes de un evento coronario isquémico en un país mediterráneo.
Consumption of EVOO in the reduction of the risk of suffering from cardiovascular diseases, cancer or diabetes.
The Mediterranean diet, characterised by a high consumption of EVOO, has a strong correlation between its consumption and a lower incidence of cardiovascular disease, coronary heart disease, myocardial infarction, overall incidence of cancer, neurodegenerative diseases and diabetes.
https://www.revclinesp.es/es-la-dieta-mediterranea-optima-contra-articulo-S0014256518301498
Reference: Ros, E. (2018). Revista Clínica Española, 218(5), 241-243. doi: 10.1016/j.rce.2018.04.011
22- Olive oil consumption and human health: A narrative review.
Effects on breast cancer or type 2 diabetes associated with regular consumption of EVOO
Olive oil consumption shows a protective role on breast cancer incidence, along with effects on type 2 diabetes, confirming the beneficial effects on human health.
https://www.maturitas.org/article/S0378-5122(18)30652-2/fulltext
Reference: Foscolou, A., Critselis, E., & Panagiotakos, D. (2018). Maturitas, 118, 60-66. doi:10.1016/j.maturitas.2018.10.013
23- Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis.
Improved liver function with EVOO consumption
The study shows that both olive leaf extract and olive oil prevent the induction of fluoxetine, thus improving liver function, attenuating oxidative stress, inflammation and apoptosis, along with improving antioxidant defences.
https://www.sciencedirect.com/science/article/abs/pii/S0753332217360286?via%3Dihub
Reference: Elgebaly, H., Mosa, N., Allach, M., El-massry, K., El-Ghorab, A., Al Hroob, A., & Mahmoud, A. (2018). Biomedicine & Pharmacotherapy, 98, 446-453. doi: 10.1016/j.biopha.2017.12.101
24- Olive oil and its principal bioactive compound: Hydroxytyrosol- A review of the recent literature.
Prevention of neurological disorders, inflammatory complications and cancer with bioactive compounds from EVOO
The fatty acids in olive oil promote mental health and prevent neurological disorders, inflammatory complications and cancer.
https://europepmc.org/article/agr/ind606362452
Reference: Wani, T., Masoodi, F., Gani, A., Baba, W., Rahmanian, N., & Akhter, R. et al. (2018). Trends in Food Science & Technology, 77, 77-90. doi: 10.1016/j.tifs.2018.05.001
25- Olive oil and prevention of chronic diseases: Summary of an International conference.
Relationship between the consumption of EVOO and its phenolic compounds on the state of wellbeing
The consumption of EVOO is associated with longevity and well-being, due to the beneficial effects it has on human health.
https://www.nmcd-journal.com/article/S0939-4753(18)30126-1/fulltext
Reference: Visioli, F., Franco, M., Toledo, E., Luchsinger, J., Willett, W., Hu, F., & Martinez-Gonzalez, M. (2018). Nutrition, Metabolism And Cardiovascular Diseases, 28(7), 649-656. doi: 10.1016/j.numecd.2018.04.004
26- Documento de recomendaciones de la SEA 2018. El estilo de vida en la prevención cardiovascular.
EVOO as a main source of monounsaturated fats supports cardiovascular health
The paper concludes that EVOO has health-promoting effects, rich in polyphenols, with EVOO being the main source of monounsaturated fats that provide better cardiovascular health, and links it to the Mediterranean diet.
https://www.sciencedirect.com/science/article/pii/S0214916818300834?via%3Dihub
Reference: Pérez-Jiménez, F., Pascual, V., Meco, J., Pérez Martínez, P., Delgado Lista, J., Domenech, M., Estruch, R., León-Acuña, A., López-Miranda, J., Sánchez-Ramos, A., Soler i Ferrer, C., Soler-Rivas, C., Solá Alberich, R., Valdivielso, P. and Ros, E., 2018. Clínica e Investigación en Arteriosclerosis, 30(6), pp.280-310.
27- Olive oil and its principal bioactive compound: Hydroxytyrosol- A review of recent literature.
Antimicrobial properties of EVOO
Analysis of the antimicrobial, antiviral, cardiovascular, carcinogenic and similar activities of EVOO.
https://www.sciencedirect.com/science/article/pii/S0924224417305940
Reference: Wani, T., Masoodi, F., Gani, A., Baba, W., Rahmanian, N., & Akhter, R. et al. (2018). Trends in Food Science & Technology, 77, 77-90. https://doi.org/10.1016/j.tifs.2018.05.001
28- Cambios en el Índice de Hígado Graso con una intervención con dieta mediterránea: seguimiento de 6 años ensayo PREDIMED-Málaga.
Delaying the progression of non-alcoholic fatty liver disease with EVOO consumption in the Mediterranean diet
Consuming a Mediterranean diet could delay or slow down the natural progression of NAFLD (non-alcoholic fatty liver disease), and could be beneficial for the prevention and treatment of NAFLD.
https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-cambios-el-indice-higado-graso-S00 25775316306807
Reference: Cueto-Galán, R., Barón, F., Valdivielso, P., Pintó, X., Corbella, E., Gómez-Gracia, E., & Wärnberg, J. (2017). Medicina Clínica, 148(10), 435-443. doi: 10.1016/j.medcli.2016.11.032
29- Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.
Protective effect of EVOO on memory alterations or synaptic integration
Protective effect of extra virgin olive oil in the modulation of tau phosphorylation, memory alterations, synaptic integration and neuroinflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553230/
Reference: Roede, J. (2017). Annals Of Clinical And Translational Neurology, 4(10), 762-762. doi:10.1002/acn3.442
30- Oleocanthal ameliorates amyloid-β oligomers toxicity on astrocytes and neuronal cells: In-vitro studies.
EVOO as a inhibitor of Alzheimer’s disease
The study demonstrates how EVOO ameliorates the pathology of Alzheimer’s disease, producing an improvement in cognitive function in animals, suggesting a protective potential and reducing the risk of developing Alzheimer’s disease.
https://www.sciencedirect.com/science/article/abs/pii/S0306452217302348?via%3Dihub5
Reference: Batarseh YS, Mohamed LA, Al Rihani SB, Mousa YM, Siddique AB, El Sayed KA, Kaddoumi ANeuroscience 2017, 352:204-215.
31- Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials.
Weight loss and reduced risk of diabetes during pregnancy with Mediterranean diet
The study concludes that the Mediterranean diet and physical activity during pregnancy reduce weight gain and a lower the probability of delivering by caesarean.
https://www.bmj.com/content/358/bmj.j3991
Reference: p.j3991. BMJ, 2017.
32- Anti-HSV type 1 activity of olive leaves extract crude form acting as a microemulsion dosage form.
Antiviral activity of emulsion-forming olive leaf extract against Type 1 HSV
The study demonstrates the antiviral activity of the extract obtained from olive leaves forming a microemulsion, thanks to the activity of the oleuropein it contains, against type 1 HSV.
https://academicjournals.org/journal/AJMR/article-full-text-pdf/E09C2B158944
Reference: Rania, A., Alaa, E., Mostafa, A., Rania, H., & Nariman, A. (2016). African Journal Of Microbiology Research, 10(22), 820-828. https://doi.org/10.5897/ajmr2016.7972
33- Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial. A Randomized Clinical Trial
The Mediterranean diet, rich in EVOO, could help prevent breast cancer and reduce the risk of suffering from cardiovascular diseases.
The study determines that by increasing the consumption of EVOO by 5%, the risk of breast cancer decreases by 28%.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2434738
Reference: Estefanía Toledo, MD, MPH, PhD1,2; Jordi Salas-Salvadó, MD, PhD2,3; Carolina Donat-Vargas, PharmD1,2; et al
34- Comparative Analysis of Pancreatic Changes in Aged Rats Fed Life Long with Sunflower, Fish, or Olive Oils.
EVOO helps the improvement for pancreatitis
Improvement of pancreatitis due to the content of antioxidants and antimicrobial agents in virgin olive oil.
https://academic.oup.com/biomedgerontology/article/69/8/934/533348?searchresult=1
Reference: The Journals of Gerontology: Series A, Volume 69, Issue 8, August 2014, Pages 934–944
35- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet (PREDIMED)
EVOO consumption and relationship with cardiovascular disease
Among people at high cardiovascular risk, a Mediterranean diet supplemented with extra virgin olive oil or nuts reduced the incidence of major cardiovascular events.
https://www.nejm.org/doi/full/10.1056/NEJMoa1200303?query=TOC#t=abstract
Reference: Ramón Estruch, M.D., Ph.D., Emilio Ros, M.D., Ph.D., Jordi Salas-Salvadó, M.D., Ph.D., Maria-Isabel Covas, D.Pharm., Ph.D., Dolores Corella, D.Pharm., Ph.D., Fernando Arós, M.D., Ph.D., Enrique Gómez-Gracia, M.D., Ph.D., Valentina Ruiz-Gutiérrez, Ph.D., Miquel Fiol, M.D., Ph.D., José Lapetra, M.D., Ph.D., Rosa Maria Lamuela-Raventos, D.Pharm., Ph.D., Lluís Serra-Majem, M.D., Ph.D., et al.
36- Prevención primaria de la enfermedad cardiovascular con una dieta mediterránea.
30% decrease in the incidence of cardiovascular effects with EVOO consumption
The study indicates that there is a relative risk reduction of up to 30% of suffering cardiovascular events for patients who followed a Mediterranean diet with olive oil as the main source of monounsaturated fats.
https://www.revespcardiol.org/en-dieta-mediterranea-prevencion-delaenfermedad-cardiovascula r-articulo-S0300893213002492?redirect=true
Reference: Bailén Almorox, R. (2013). Revista Clínica Española, 213(7), 355-356. doi:10.1016/j.rce.2013.04.011
37- Factores dietéticos asociados al cáncer de próstata. Beneficios de la dieta mediterránea.
Relationship between the oleic acid content of EVOO and the regulation of oncogenes related to prostate cancer.
Evidence of direct and indirect factors related to EVOO, which produce a reduction in prostate cancer.
https://www.elsevier.es/es-revista-actas-urologicas-espanolas-292-articulo-factores-dieteticos-as ociados-al-cancer-S0210480611003202
Reference: Ferrís-Tortajada, J., Berbel-Tornero, O., García-Castell, J., Ortega-García, J., & López-Andreu, J. (2012). Actas Urológicas Españolas, 36(4), 239-245. doi: 10.1016/j.acuro.2011.08.002
38- Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L.var.grandiflorum
EVOO as a treatment against hepatitis B
The study suggests important findings that EVOO consumption could play an important role in the treatment of Hepatitis B.
https://www.sciencedirect.com/science/article/pii/S0378874109004073?via%3Dihub
Reference: Zhao G., Yin Z., DongJ. J. Ethnopharmacol. 2009 Sep 7;125(2):265-8. Epub 2009 Jul 4
39- Aceite de oliva, clave de vida en la Cuenca Mediterránea.
EVOO consumption linked to improved lipid profile
The study compiles other studies on EVOO, highlighting its numerous health benefits
https://dialnet.unirioja.es/servlet/articulo?codigo=2673034
Reference: Sánchez-Muniz, F. J. (2007). Anales De La Real Academia Nacional De Farmacia, (. 4 3), 653.
40- The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV).
In vitro inhibition of VHSV activity from olive leaf extract.
Decrease of about 30% in the effectiveness of VHSV by incubation of VHSV in a medium with olive oil leaves.
https://www.sciencedirect.com/science/article/pii/S0166354205000677?via%3Dihub
Reference: MICOL, V., CATURLA, N., PEREZFONS, L., MAS, V., PEREZ, L., & ESTEPA, A. (2005). Antiviral Research, 66(2-3), 129-136.
41- Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves.
EVOO with possible use in high blood pressure
Use of EVOO oleanoic acid as a remedy for high blood pressure complicated by heart failure.
https://www.sciencedirect.com/science/article/pii/S037887410200332X
Reference: Somova LI, Shode FO, Ramnanan P, Nadar A. J Ethnopharmacol 2003, 84 (2-3): 299-305.
42- Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment.
Olive leaf extract as an inhibitor of acute HIV-1 infection
Inhibition of acute HIV-1 infection, cell-to-cell transmission and HIV-1 replication by olive leaf extract.
https://www.sciencedirect.com/science/article/pii/S0006291X03012920
Reference: Lee-Huang, S., Zhang, L., Lin Huang, P., Chang, Y., & Huang, P. (2003). Biochemical And Biophysical Research Communications, 307(4), 1029-1037. https://doi.org/10.1016/s0006-291x(03)01292-0
43- Los beneficios del aceite de oliva a largo plazo, avalados por primera vez por una investigación estadounidense.
A higher intake of olive oil is related to a lower risk of total and cause-specific mortality.
It also reveals that replacing other fats with an equivalent amount of olive oil reduces premature mortality.
https://www.unav.edu/noticias/-/contents/11/01/2022/los-beneficios-del-aceite-de-oliva-a-largo- plazo-avalados-por-primera-vez-por-una-investigacion-estadounidense/content/lovPblW1fC70/36 420562
Reference: Profesor Miguel Ángel Martínez-González, catedrático de la Universidad de Navarra e investigar del CIBEROBN, Marta Guasch-Ferré, Frank Hu.
44- Add Olive Oil to cut risk of early death, study suggests.
Chan School researchers see impact in cardiovascular and respiratory conditions, cancer, neurodegenerative disease
The researchers also found that people who consumed olive oil instead of animal fat had a lower risk of total and cause-specific mortality.
https://news.harvard.edu/gazette/story/2022/01/olive-oil-consumption-lowers-risk-of-premature -death-study-suggests/
Reference: Amy Roeder, Harvard Chan School Communications. Harvard Gazette, researchers from Harvard T.H. Chan School of Public Health.
45- Synergistic Effect of Squalene and Hydroxytyrosol on Highly Invasive MDA-MB-231 Breast Cancer Cells
The combined action of two EVOO minority compounds (hydroxytyrosol and squalene) with an antitumour effect on highly metastatic breast cancer cells.
Both isolated compounds were previously tested without showing any antitumour effect on highly invasive MDA-MB-231 breast cancer cells, but the current results show that HT at 100 μM, combined with different concentrations of SQ, could have antitumour effects.
https://www.mdpi.com/2072-6643/14/2/255
Reference: Dr. José Juan Gaforio, Cristina Sánchez-Quesada, Francisco Gutiérrez-Santiago, Carmen Rodríguez-García. Nutrients 2022, 14 (2) 255; https://doi.org/10.3390/nu14020255. Special Issue Clinical Nutrition for Prevention and Treatment of Chronic Diseases.
46- Aceite de Oliva y Salud.
These favourable results for olive oil have been replicated in the best follow-up studies on both sides of the Atlantic.
There is no doubt that consuming olive oil reduces cardiovascular risk.
https://eu.docworkspace.com/d/sAPvw18Tj67OHAfe17_WrpxQ
Reference: Dr. Miguel Ángel Martínez-González, Professor of Preventive Medicine and Public Health (University of Navarra and Harvard University). Published by Sur Andalucía.
47- Risk of first non-fatal myocardial infarction negatively associated with olive oil consumption: a case-control Study in Spain.
Olive oil is the main source of dietary lipids in most Mediterranean countries.
In these Mediterranean countries, mortality and incidence rates of coronary heart disease (CHD) are the lowest in Europe.
https://pubmed.ncbi.nlm.nih.gov/11980820/
Reference: E. Fernández-Jarne, E Martínez-Losa, M Prado-Santamaría, C Brugarolas-Brufau, M Serrano-Martínez, M A Martínez-González. Published by the International Journal of Epidemiology. PMID: 11980820. Doi: 10.1093/intjepid/31.2.474.
48- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts.
Observational cohort studies and a secondary prevention trial have shown inverse associations between adherence to the Mediterranean diet and cardiovascular risk.
Although international comparisons and mechanistic reasons support the hypothesis that high olive oil intake may prevent coronary heart disease, limited data are available from studies of individuals.
https://pubmed.ncbi.nlm.nih.gov/29897866
Reference: Ramón Estruck, Emilio Ros, Jordi Salas-Salvadó, María-Isabel Covas, Dolores Corella, Fernando Arós, Enrique Gómez-Gracia, Valentina Ruiz-Gutiérrez, Miquel Fiol, José Lapetra, Rosa M Lamuela-Raventos, Lluís Serra-Majem, Xavier Pintó, Josep Basora, Miguel A. Muñoz, José V Sorlí, J. Alfredo Martínez, Montserrat Fitó, Alfredo Gea, Miguel A Hernán, Miguel A Martínez Gonzalez, Predimed Study Investigators. Published by The New England Journal of Medicine. PMID: 29897866, Doi: 10.1056/NEJMoa1800389.
49- Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults.
First large long-term US population-based study.
Olive oil consumption has been shown to reduce the risk of cardiovascular disease, but its associations with total and cause-specific mortality are unclear.
https://pubmed.ncbi.nlm.nih.gov/35027106
Reference: Marta Guasch-Ferré, Yanping Li, Walter C Willett, Qi Sun, Laura Sampson, Jordi Salas-Salvadó, Miguell A Martínez-González, Meir J. Stamper, Frank B Hu. Journal of the Americann College of Cardiology 2022 Jan 18. Doi: 10.1016/j.jacc.2021.10.041.
50- Olive Oil consumption is associated with a lower risk of cardiovascular disease and stroke.
Carolina Donat-Vargas, found that olive oil protects against severe cardiovascular disease.
Olive oil is associated with a lower risk of cardiovascular disease and stroke. The maximum benefit could be obtained with an intake between 20 and 30 g/day.
https://pubmed.ncbi.nlm.nih.gov/34872046/
Reference: Carolina Donat-Vargas, Helena Sandoval-Insausti, José L Peñalvo, Maria Concepción Moreno Iribas, Pilar Amiano, Maira Bes-Rastrollo, Esther Molina-Montes, Belén Moreno-Franco, Antonio Agudo, Cristina Lasheras Mayo, Martín Laclaustra, Carment De La Vuente Arrillaga, María Dolores Chirlaque Lopez, María José Sánchez, Miguel Angel Martínez-Gonzalez, Guallar-Castillón Pilar. Published by Clinical Nutrition (Edinburgh, Scotland), doi: 10.1016/j.clnu.2021.11.002. Epub 2021, Nov. 15.
51- Type does matter. Use Virgin Olive oil as your preferred fat to reduce your risk of breast cancer: case-control EpiGEICAM study.
EVOO vs. OO Breast Cancer Case control
In the predimed trial including breast cancer incidence as a secondary outcome, the protective effect detected appeared to be mainly due to the high consumption of virgin olive oil.
https://eu.docworkspace.com/d/sAJvgLQXj67OHAYHBmPyrpxQ
Reference: Carolina Donat-Vargas, Angel Guerrero-Zotano, Virginia Lope, Begoña Bermejo, Ana Casas, José Manuel Baena-Cañada, Silvia Antolín, Pedro Sánchez-Roviera, Antonio Antón, José Angel Garcia-Saénz, Manuel Ramos, Montserrat Muñoz, Ana de Juan, Carlos Jara Sánchez, José Ignacio Chacón, Miguel Gil-Gil, Raquel Andrés Conejero, Antonio Llombart, Susana Bezares, Nerea Fernández de Larrea-Baz, Beatriz Pérez-Gómez, Miguel Martín and Marina Pollán. European Journal of Clinical Nutrition.
52- Dietary modulation of gut microbiota for the relief of irritable bowel syndrome.
https://pubmed.ncbi.nlm.nih.gov/34349876/
Reference: Mi-Young Kim and Sang-Woon Choi. Nutrition Research and Practice. Doi: 10.4162/nrp.2021.15.4.411.
53- Polyphenols, Olive oil and Colonrectal cancer: the effect of Mediterranean Diet in the prevention.
In recent years, scientific research has shown that the incidence of various diseases, including some cancers, is relatively low in Mediterranean countries compared to other European countries or North America.
This supports the hypothesis that the Mediterranean diet, rich in bioactive food components, including methyl group donors, polyphenols and fatty acids, is effective in terms of prevention.
https://pubmed.ncbi.nlm.nih.gov/35075094/
Reference: Francesco Serra, Francesco Spatafora, Silvia Toni, Alberto Farinetti, Roberta Gelmini, Anna Vittoria Mattioli. Acta Biomed. 2022. Doi: 10.23750/abm.v92i6.10390.
54- Potential Health Benefits of Olive Oil and Plant Polyphenols.
Bioactive polyphenols are naturally occurring compounds of various chemical structures.
Polyphenols are believed to reduce morbidity and/or slow the development of cardiovascular and neurodegenerative diseases, as well as cancer.
https://pubmed.ncbi.nlm.nih.gov/29495598/
Reference: Monika Gorzynik-Debicka, Paulina Przycchodzen, Francesco Cappello, Alicja Kuban-Jankowska, Antonella Marino Gammazza, Narcyz Knap, Michal Wozniak and Magdalena Gorska-Ponikowska. International Journal of molecular sciences 2018 Feb 28, doi:10.3390/ijms19030686.
55- Antioxidant and protective effects of extra virgin olive oil incorporated with dially lsulfide against CCI4-induced acute liver injury in mice.
https://www.researchgate.net/publication/355645526_Antioxidant_and_protective_effects_of_ex tra_virgin_olive_oil_incorporated_with_diallyl_sulfide_against_CCl4-induced_acute_liver_injury_i n_mice
Reference: Emna Habibi, Tarek Baati, Leila Njim, Yassine M ́Rabet, Karim Hosni. October 2021, Food Science & Nutrition Doi:10.1002/fsn3.2638
56- Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review.
Olive derivatives, especially olive oil and leaf extract, could stimulate thyroid function.
Therapeutic applications of olive oil and leaf extract, especially in individuals with hypothyroidism, require further validation through human studies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915253/
Reference: Kok-Lun Pang, Johanna Nathania Lumintang, and Kok-Yong Chin. Nutients 2021, Published online 2021 Feb 6. Doi: 10.3390/nu13020529.
57- The Synergistic Beneficial Effect of Thyme Honey and Olive Oil against Diabetes and Its Complications Induced by Alloxan in Wistar Rats
The present study focused on the evaluation of the hypoglycaemic and protective properties of two natural products widely used in complementary and alternative medicine (thyme honey and olive oil).
The results obtained showed that thyme honey or olive oil, and especially their combination, significantly improved blood glucose levels and protect against diabetes-induced metabolic changes and complications.
https://pubmed.ncbi.nlm.nih.gov/34594393/
Reference: Hajar Lafraxo, Meryem Bakour, Hassan Laaroussi, Asmae El Ghouizi, Driss Ousaaid, Abderrazak Aboulghazi, Badiaa Lyoussi. Evidence Based Complementary Alternative Medicine 2021, Sep 20; doi: 10.1155/2021/9949056.
This literature review was conducted by the QvExtra! International Association in April 2020. Please retain the authorship of the author in references to it.
